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Top 10 most revolutionary Nature articles of all time.

Template from Watson and Crick molecular Model, 1953.
Nature is one of the most recognizable and most cited scientific journals of the world with an impact factor of 43 (2018). Nature is edited and published in the United Kingdom by a scientific publishing company Springer Nature. Nature is a weekly journal. Being published in nature is very prestigious.
Recently, on 04 November 2019, Nature published the top 10 most influential nature papers of all time. Here is the list with no particular order.

 The structure of DNA:
On 25th April 1953, James Watson and Francis Crick announced in Nature that they had elucidated the structure of DNA.  In the early 1950s, the identity of genetic material was still a matter of debate. This discovery of the helical structure of double-stranded DNA settled the matter and change the history of biology forever.

The advent and rise of monoclonal antibodies:
In 1975, Georges Kohler and Cesar Milstein first report how cell lines could be made to produce an antibody of known specificity.

Cell identity reprogrammed:
In the 1940s, people believe that the differentiation of cells is irreversible. However, in 1950s, Gurdon and colleagues concluded through their research that Developmental clock can be This laid the foundation of modern methods of reprogramming cell identity and promising new regenerative therapies.

 Australopithecus provided insight into human evolution
In 1925, Raymond Dart published a report of an African fossil of a previously unknown genus Australopithecus. This the finding helps us understand how humans evolved after its split with apes in the evolutionary tree.

Discovery of Antarctic Ozone hole:
In 1985, Joe Farman and colleagues reported that the stratospheric ozone layer was only about two-thirds as thick as seen in earlier decades. The phenomenon became known as the Antarctic ozone hole. This discovery helped established one of the most successful global environmental policies of the twentieth century.

Discovery of patch-clamp techniques:
Initially, it was developed to record currents of ions flowing through channel proteins in the membranes of cells. The patch-clamp technique has become a true stalwart of the neuroscience toolbox.

Discovery of C60:
In 1985, scientists reported the discovery of cage-like carbon molecule C60. It paves the way for materials such as graphene and carbon nanotube and was a landmark in the emergence of nanotechnology.

Birth of class of nanomaterial:
In 1992, Kresge et el report a breakthrough in material science, a material that is regularly arranged with mesoscopic diameters (between 2 and 50 nanometres).

 Detection of strange particles:
In 1947, scientists first reported an unseen particle which is now called neutral kaon. This work led to the establishment of elementary particles known as quarks.

The first exoplanet found around a sun-like star:
In 1995, astronomers detected a blistering hot Jupiter mass planet orbiting closer to its hot star than the mercury is to the sun. This discovery recast our thinking of how planets form and let to a a new era of exoplanetary exploration.



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